研究进展
- Surface grafted semiconductor layer via surface initiated ring-opening polymerization of L-lysine NCA derivatives
- Tunable Organogelator from Alkyl-Polypeptide Diblock Prepared by Ring-Opening Polymerization
- Irreversible Low Critical Solution Temperature Behaviors of Thermal-responsive OEGylated Poly(L-cysteine) Containing Disulfide Bonds
- Fibril Aggregates Formed by a Glatiramer-Mimicking Random Copolymer of Amino Acids
- New thermal-responsive polymers based on alanine and (meth)acryl amides
- Oxidation-responsive OEGylated poly-L-cysteine and solution properties studies
- Supramolecular Hydrogels Assembled from Nonionic Poly(ethylene glycol)-b-Polypeptide Diblock Containing OEGylated Poly-L-glutamate
- Effects of the surface charge on the stability of PEG-b-PCL micelles: simulation of the interactions between charged micelles and plasma components
- Surface-Induced Hydrogelation Inhibits Platelet Aggregation
- Stimuli-responsive polypeptide materials prepared by ring-opening polymerization of α-amino acid N-carboxyanhydrides
- Effects of molecular weight on thermal responsive property of PEGylated poly-L-glutamates
- Facile Synthesis of Dendrimers Combining aza-Michael Addition with
- Peptide Hydrogels Assembled from Nonionic Alkyl-polypeptide Amphiphiles Prepared by Ring-Opening Polymerization
- Synthesis of toothbrush copolypeptides based on polylysine backbone
- One-step synthesis of water dispersible silica nanoplates
- Conformation-specific Self-assembly of Thermo-responsive Poly(ethylene glycol)-b-polypeptide Diblock Copolymer
- Coassembly of Poly(ethylene glycol)-block-Poly(glutamate sodium)
- Thermoresponsive Oligo(ethylene glycol) Functionalized Poly‑L‑cysteine
研究进展
Facile Synthesis of Dendrimers Combining aza-Michael Addition with Thiol-yne Click Chemistry
JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY 2013, 51, 708–715.
Yong Shen, Yinan Ma, Zhibo Li*
We report a highly efficient approach to prepare dendrimers by taking advantage of the orthogonal characteristic of aza-Michael addition and thiol-yne reactions. A fifth generation dendrimer was synthesized within five steps without protection/activation procedures. The reactions proceed under benign conditions without byproducts, and the target products can be easily purified via extraction or precipitation without chromatography. The structure of each generation dendrimer was characterized using NMR spectroscopy, size exclusion chromatography, and mass spectrometry. The obtained dendrimers can have peripheral amine or alkyne groups. We demonstrated that these groups can be used for selective and specific conjugation with various functional groups.