环境友好的催化反应
环境友好的催化反应
据报道，超过70%的化工过程使用溶剂，每年大约2000万吨溶剂挥发。因此，寻找环境友好的反应介质替代传统的有机溶剂是绿色化学的重要研究内容，同时，也为均相催化剂的分离与回收提供了新的途径。为此，基于水、离子液体和液态聚乙二醇等非传统反应介质的特色性质，我们开展了环境友好的不对称催化反应研究。研究发现离子液体和液态聚乙二醇等作为新的绿色反应介质，并非有机溶剂的简单替换，不仅有利于提高催化剂的选择性和稳定性，而且更加方便催化剂的分离与回收，为手性催化剂的实际应用奠定了基础。
Figure. Asymmetric Catalysis in Polyethylene Glycols and Ionic Liquids
发表论文
16. Yong Li, Yan-Mei He, Qing-Hua Fan, "Ionic Liquids in Transition Metal-Catalyzed Enantioselective Reactions", Top. Organomet. Chem. 2015, 51, 323–348.
15. Zi-Yuan Ding, Tianli Wang, Yan-Mei He, Fei Chen, Hai-Feng Zhou, Qing-Hua Fan,* Qingxiang Guo,* and Albert S. C. Chan, "Highly Enantioselective Synthesis of Chiral Tetrahydroquinolines and Tetrahydroisoquinolines by Ruthenium-Catalyzed Asymmetric Hydrogenation in Ionic Liquid", Adv. Synth. Catal. 2013, 355, 3727-3735.
14. Fei Chen, Tianli Wang, Yanmei He, Ziyuan Ding, Zhiwei Li, Lijin Xu and Qing-Hua Fan,* "Asymmetric Hydrogenation of N-Alkyl Ketimines with Phosphine-Free, Chiral, Cationic Ru-MsDPEN Catalysts", Chem. Eur. J. 2011, 17, 1109-1113. <Highlight by Synfacts 2011, 4, 420.>
13. Zhi-Jian Wang, Hai-Feng Zhou, Tian-Li Wang, Yan-Mei He and Qing-Hua Fan,* "Highly Enantioselective Hydrogenation of Quinolines under Solvent-Free or Highly Concentrated Conditions", Green Chem. 2009, 11, 767-769.
12. Haifeng Zhou, Zhiwei Li, Zhijian Wang, Tianli Wang, Lijin Xu, Yanmei He, Qing-Hua Fan,* Jie Pan, Lianquan Gu and Albert S. C. Chan,* "Hydrogenation of Quinolines Using a Recyclable Phosphine-Free Chiral Cationic Ruthenium Catalyst: Enhancement of Catalyst Stability and Selectivity in an Ionic Liquid", Angew. Chem. Int. Ed. 2008, 47, 8464-8467.
11. HaifengZhou, Qing-Hua Fan,* Yanmei He, Lianquan Gu* and Albert S. C. Chan,*"Application of Liquid Poly( Ethylene Glycol)s as Green Reaction Media in Organic Reactions", Prog. Chem. 2007, 19, 1517-1528.
10. Sau Hing Chan, Kim Hung Lam,* Yue-Ming Li, Lijin Xu, Weijun Tang, Fuk Loi Lam, Wai Hung Lo, Wing Yiu Yu, Qing-Hua Fan* and Albert S. C. Chan,* "Asymmetric Hydrogenation of Quinolines with Recyclable and Air-Stable Iridium Catalyst Systems", Tetrahedron: Asymmetry 2007, 18, 2625-2631.
9. Hai-Feng Zhou, Qing-Hua Fan,* Yi-Yong Huang, Lei Wu, Yan-Mei He, Wei-Jun Tang, Lian-Quan Gu* and Albert S. C. Chan,* "Mixture of Poly(Ethylene Glycol) and Water as Environmentally Friendly Media for Efficient Enantioselective Transfer Hydrogenation and Catalyst Recycling", J. Mol. Catal. A: Chem. 2007, 275, 47-53.
8. Lijin Xu, Kim Hung Lam, Jiwu Ruan, Qing-Hua Fan and Albert S. C. Chan, "Ruthenium Catalyzed Asymmetric Hydrogenation of α- and β-Ketoesters in Room Temperature Ionic Liquids Using Chiral P-Phos Ligand", ACS Symposium Series 2007, 950, 224-234.
7. Hai-Feng Zhou, Qing-Hua Fan,* Wei-Jun Tang, Li-Jin Xu, Yan-Mei He, Guo-Jun Deng, Li-Wen Zhao, Lian-Quan Gu* and Albert S. C. Chan,* "Polyethylene Glycol as an Environmentally Friendly and Recyclable Reaction Medium for Enantioselective Hydrogenation", Adv. Synth. Catal. 2006, 348, 2172-2182.
6. Lijin Xu, Kim Hung Lam, Jianxin Ji, Jing Wu, Qing-Hua Fan,* Wai-Hung Lo and Albert S. C. Chan,* "Air-Stable Ir-(P-Phos) Complex for Highly Enantioselective Hydrogenation of Quinolines and Their Immobilization in Poly(Ethyleneglycol) Dimethyl Ether (DMPEG)", Chem. Commun. 2005, 1390-1392. <Highlight by Synfacts 2005, 0, 37.>
5. Kim Hung Lam, Lijin Xu, Lichun Feng, Jiwu Ruan, Qing-Hua Fan and Albert S. C. Chan,* "Ruthenium Catalyzed Asymmetric Hydrogenation of α- and β-keto Esters in Ionic Liquids Using Chiral P-Phos Ligand", Can. J. Chem. 2005, 83, 903-908.
4. Qing-Hua Fan, Yue-Ming Li* and Albert S. C. Chan,* "Recoverable Catalysts for Asymmetric Organic Synthesis", Chem. Rev. 2002, 102, 3385-3466.
3. Qing-Hua Fan,* Guo-Jun Deng, Chi-Ching Lin and Albert S. C. Chan,* "Preparation and Use of Meo-PEG-Supported Chiral Diphosphine Ligands: Soluble Polymer-Supported Catalyst for Asymmetric Hydrogenation", Tetrahedron: Asymmetry 2001, 12, 1241-1247.
2. Qing-Hua Fan,* Guojun Deng, Xiaomin Chen, Wenchun Xie, Dazhi Jiang, Dongsheng Liu and Albert S. C. Chan,* "A Highly Effective Water-soluble Polymer-supported Catalyst for the Two-phase Asymmetric Hydrogenation: Preparation and Use of a PEG-bound BINAP Ligand", J. Mol. Catal. A: Chem. 2000, 159, 37-43.
1. Qing-Hua Fan, Chang-Yu Ren, Chi-Hung Yeung, Wen-Hao Hu and Albert S. C. Chan,* "Highly Effective Soluble Polymer-Supported Catalyst for Asymmetric Hydrogenation", J. Am. Chem. Soc. 1999, 121, 7407-7408.